A Resveratrol Analogue Promotes ERKMAPK–Dependent Stat3 Serine and Tyrosine Phosphorylation Alterations and Antitumor Effects In Vitro against Human Tumor Cells
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چکیده
منابع مشابه
A Resveratrol Analogue Promotes ERK–Dependent Stat3 Serine and Tyrosine Phosphorylation Alterations and Antitumor Effects In Vitro against Human Tumor Cells
(E )-4-(3,5-dimethoxystyryl)phenyl acetate (Cmpd1) is a resveratrol analog that preferentially inhibits glioma, breast, and pancreatic cancer cell growth, with IC50 values of 6–19 mM. Notably, the human U251MG glioblastoma tumor line is the most sensitive, with an IC50 of 6.7 mM, compared with normal fibroblasts, which have an IC50 . 20 mM. Treatment of U251MG cells that harbor aberrantly activ...
متن کاملA Resveratrol Analogue Promotes ERKMAPK-Dependent Stat3 Serine and Tyrosine Phosphorylation Alterations and Antitumor Effects In Vitro against Human Tumor Cells.
(E)-4-(3,5-dimethoxystyryl)phenyl acetate (Cmpd1) is a resveratrol analog that preferentially inhibits glioma, breast, and pancreatic cancer cell growth, with IC50 values of 6-19 μM. Notably, the human U251MG glioblastoma tumor line is the most sensitive, with an IC50 of 6.7 μM, compared with normal fibroblasts, which have an IC50 > 20 μM. Treatment of U251MG cells that harbor aberrantly active...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2015
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.115.099093